By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a consultant to new thoughts and ways to choosing and characterizing small molecules in early drug discovery. Biophysical equipment are reasserting their application in drug discovery and during a mixture of the increase of fragment-based drug discovery and an elevated concentrate on extra nuanced characterisation of small molecule binding, those tools are enjoying an expanding function in discovery campaigns.
This textual content emphasizes functional concerns for choosing and deploying center biophysical process, together with yet now not constrained to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics lined include:
• layout concerns in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing goals and screening reagents with HDX-MS
• Microscale thermophoresis equipment (MST)
• Screening with susceptible Affinity Chromatography
• how you can check compound place of abode time
• 1D-NMR equipment for hit identification
• Protein-based NMR equipment for SAR development
• case reviews integrating a number of biophysical methods
This textual content is perfect for tutorial investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Extra info for Applied Biophysics for Drug Discovery
Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler